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Here are my Scientific Publications

BOOKS AND ARTICLES:

(books are in bold)

  1. Blackburn, G. M., and Cohen, J. S. Chemical Oxidative Phosphorylation. In: Grayson and Griffiths (eds.), Topics in Phosphorus Chemistry, Vol.  6. New York: Wiley-Interscience, 1969.

  2. Cohen, J. S. Nuclear Magnetic Resonance Investigations of Interactions of Biomolecules. In: C. Nicolau (ed.) Experimental Methods in Biophysical Chemistry, pp. 521-588. London: Wiley & Sons, 1973.

  3. Hayes, M. B., Cohen, J. S., and McNeel, N. L. NMR of Amino Acids, Peptides and Proteins, Magnetic Resonance Reviews. 3: 3491-3496, 1974.

  4. Egan, W., Liu, T.-Y., Cohen, J. S., and Robbins, J. B. Studies in Meningococcal Polysaccharides: Characterization of the Antigens from E Coli: Bos-12 by 13C NMR Spectroscopy. In: E. R. Klein and T. S. Klein (eds.), Proc. of the Second Intl. Conf. on Stable Isotopes, pp. 728- 733. Springfield, Va.: Natl. Tech. Information Services, 1976.

  5. Egan, W., Shindo, H., and Cohen, J. S. Carbon-13 NMR Studies of Proteins, Ann. Rev. Biophys. Bioeng. 6: 383-417, 1977.

  6. Cohen, J. S. Nuclear Magnetic Resonance Studies of Biologically Relevant Isotopes Other than Hydrogen, Crit. Rev. Biochem. 5: 25-43, 1978.

  7. Portugal, F. H., and Cohen, J. S. A Century of DNA. Boston: MIT Press, 1977; Paperback edition, 1980 (with a Foreword by Lord Todd, President, Royal Society).

  8. Cohen, J. S. (ed.) Magnetic Resonance in Biology, Vol. 1. New York: Wiley- Interscience, 1980.

  9. Cohen, J. S., Niu, C., Matsuura, S., and Shindo, H. Conformation, Mechanism, and Peptide-Exchange by 13C NMR Spectroscopy: Elsevier, 1980.

  10. Cohen, J. S., and Chen, C. W. 31P NMR Studies of DNA Conformation and Dynamics. In: G. Levy (ed.) New Methods and Applications of NMR Spectroscopy, pp. 249-267. Washington: ACS Monograph, 1982.

  11. Cohen, J. S. (ed.) Non-Invasive Probes of Tissue Metabolism. New York: Wiley- Interscience, 1982.

  12. Jacobsen, L., and Cohen, J. S. Intracellular pH Measurement by NMR Methods. In: J. S. Cohen (ed.) Noninvasive Probes of Tissue Metabolism, pp. 5-16: Wiley-Interscience, 1982.

  13. Wooten, J. B., Cohen, J. S., and Schejter, A. Conformational Transitions of Fericytochrome c Studied by 13C and 1H NMR Spectroscopy. In: C. Ho and W. Eaton (eds.), Interactions Between Iron and Proteins in Oxygen and Electron Transport, pp. 43-49. NY: Elsevier, 1982.

  14. Cohen, J. S. (ed.) Magnetic Resonance in Biology, Vol. 2. New York: Wiley- Interscience, 1983.

  15. Cohen, J. S., Chen, C. W., and Knop, R. Secondary Structure of DNA in Solution by NMR Methods. In: Nucleic Acids: Vectors of Life, Proceedings of the 16th Jerusalem Symposium on Quantum Chemistry and Biochemistry", 1983, pp. 127-139.

  16. Cohen, J. S., Hughes, L., and Wooten, J. B. Observations of Amino Acid Side Chains in Proteins by NMR Methods. In: J. S. Cohen (ed.) Mag. Res. Biol., Vol. 2, 1983.

  17. Cohen, J. S., Knop, R., Navon, G., and Foxhall, D. L. NMR in Biology and Medicine. In: J. V. Bannister and A. M. Michelson (eds.), Life Chemistry Reports, pp. 281-457. London: Hardwood, 1983.

  18. Chen, C. W., and Cohen, J. S. 31P NMR Studies of Polydeoxynucleotides. In: D. Gorenstein (ed.) 31P NMR Spectroscopy, pp. 233-263: Academic Press, 1984.

  19. Cohen, J. S. In: T. Govil, C. L. Khetrapal, and A. Saran (eds.), Magnetic Resonance in Biology and Medicine, pp. 77-100. New Dehli, India: Tata-McGraw Hill, 1985.

  20. Cohen, J. S., and Lyon, R. C. Metabolism of Perfused Drug-Sensitive and Resistant Breast Cancer Cells. In: S. McCarthy and F. Haseltine (eds.), Magnetic Resonance of the Reproductive System, pp. 51-66. NY: Slack, 1986.

  21. Cohen, J. S., and Lyon, R. C. Metalloporphyrins as Potential Contrast Agents in MRI. Contrast Agents in MRI, pp. 35-40: Excerpta Medica, 1986.

  22. Cohen, J. S. Phospholipid and Energy Metabolism of Cancer Cells Monitored by 31P Magnetic Resonance Spectroscopy: Possible Clinical Significance, Mayo Clin. Proc. 48: 1199-1207, 1988.

  23. Lyon, R. C., Daly, P. F., and Cohen, J. S. Effects of Drugs on the Metabolism of Human Cancer Cells in Vitro and Implanted in Mice Monitored by Magnetic Resonance Spectroscopy. In: J. W. Jaroszewski, J. Schaumberg, and M. Kofod (eds.), NMR Spectroscopy and Drug Development, pp. 508-529. Copenhagen: Benzon Fndtn. Symp, No. 26, 1988.

  24. Stein, C. A., and Cohen, J. S. Oligodeoxynucleotides as Inhibitors of Gene Expression: a Review, Cancer Res. 48: 2659-2668, 1988.

  25. Cohen, J. S. (ed) Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression: Macmillan Press, London 1989.

  26. Cohen, J. S., Lyon, R. C., and Daly, P. F. Monitoring Intracellular Metabolism by NMR, Methods Enzymol. 177: 435-438, 1989.

  27. Daly, P., and Cohen, J. S. Magnetic Resonance Spectroscopy of Tumors and Potential in vivo Clinical Applications: a Review, Cancer Res. 49: 770-779, 1989.

  28. Stein, C. A., and Cohen, J. S. Antisense Compounds: Potential Role in Cancer Therapy. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.), Important Advances in Oncology, pp. 79-97. NY: Lippincott, 1989.

  29. Stein, C. A., and Cohen, J. S. Phosphorothioate Oligodeoxynucleotide Analogs. In: J. S. Cohen (ed.) Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression, pp. 97-117. Boca Raton, Fl: CRC Press, 1989.

  30. Cohen, J. S. Antisense oligonucleotides as an approach towards anti-AIDS therapy. In: E. DeClerq (ed.) Design of Anti-AIDS Drugs, Vol. 14. New York: Elsevier, 1990.

  31. Cohen, J. S. Antisense Compounds. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.), Biologic Therapy of Cancer, pp. 763-775. NY: Lippincott, 1991.

  32. Cohen, J. S. Antisense oligonucleotides as anti-viral agents: new drugs for a new age. In: L. M. de la  Maza and E. M. Peterson (eds.), Medical Virology, Vol. 10. New York: Plenum Publishing, 1991.

  33. Cohen, J. S. Antisense oligodeoxynucleotides as antiviral agents, Antiviral Res. 16: 121-133, 1991.

  34. Cohen, J. S. Oligonucleotides as therapeutic agents, Pharmacol. Therap. 52: 211-225, 1991.

  35. Jaroszewski, J. W., and Cohen, J. S. Cellular Uptake of Antisense Oligodeoxynucletides. In: R. L. Juliano (ed.) Advanced Drug Delivery Reviews, pp. 235-250, 1991.

  36. Cohen, J. S. Chemically Modified Oligodeoxynucleotide Analogs as Regulators of Viral and Cellular Gene Expression. In: R. P. Erickson and J. Izant (eds.), Gene Regulation by Antisense Nucleic Acids, pp. 247-259. NY: Raven Press, 1992.

  37. Cohen, J. S. Informational drugs: a new concept in pharmacology. In: P. Krogsgard- Larsen and M. Kofod (eds.), New Leads and Targets in Drug Research, Vol. 33, pp. 17-32. Copenhagen: Benzon Fndtn. Symp., 1992.

  38. Cohen, J. S. Oligonucleotide therapeutics, Trends Biochem. Sci. 10: 87-91, 1992.

  39. Cohen, J. S. Phosphorothioate oligodeoxynucleotides. In: S. Crooke and B. Lebleu (eds.), Antisense Research and Applications, pp. 205-221. Boca Raton, FL: CRC Press, 1992.

  40. Cohen, J. S. Selective anti-gene therapy for cancer: principles and prospects, Tohuku J. Exp. Med. 168: 351-359, 1992.

  41. Ghosh, M., and Cohen, J. S. Oligodeoxynucleotides as antisense inhibitors of gene expression, Prog. Nucl. Acids Res. Molec. Biol. 42: 79-126, 1992.

  42. Kaplan, O., van Zijl, P. C. M., and Cohen, J. S. NMR Studies of Metabolism of Cells and Perfused Organs. In: J. Seelig and M. Rudin (eds.), In-Vivo Magnetic Resonance Spectroscopy III: Potential and Limitations. Heidelberg: Springer-Verlag, 1992.

  43. Ruiz-Cabello, J., and Cohen, J. S. NMR and the study of pathological state in cells and tissues, Intl. Rev. Cytology. 145: 1-63, 1992.

  44. Ruiz-Cabello, J., and Cohen, J.S. Phospholipid metabolism as indicators of cancer cell function, NMR Biomed. 5: 226-233, 1992.

  45. Cohen, J. S. De strategie de antisense. In: H. Schellekens (ed.) 'DNA', pp. 43-55. Amsterdam: Natuur & Techniek, 1993 (also English and German eds.).

  46. Cohen, J. S. Towards a new chemotherapy: oligonucleotide analogs as informational drugs. In: B. Huber (ed.) Cancer Therapy into the Twenty-First Century, pp. 145-162, 1994.

  47. Cohen, J. S. Gene-mimetic substances: drugs designed to intervene in gene expression, Adv. Pharm. 25: 319-339, 1994.

  48. Cohen, J. S., and Hogan, M. The new genetic medicines, Scientific American. 271 (6): 76-82, 1994.

  49. Jaroszewski, J., Roy, S., and Cohen, J. S. Nuclear magnetic resonance studies of oligonucleotides. In: S. Agrawal (ed.) Methods in Molecular Biology, Vol. 26, pp. 301-317. NY: Humana Press, 1994.

  50. Kaplan, O., and Cohen, J. S. Metabolism of breast cancer cells as revealed by non-invasive magnetic resonance spectroscopy studies, Breast Cancer Res. & Treat. 31: 285-299, 1994.

  51. Kaplan, O., and Cohen, J. S. Lymphocyte activation - 31P magnetic resonance studies of energy metabolism and phospholipid pathways, Immunomethods. 4: 139-147, 1994.

  52. Cohen, J. S., Jaroszewski, J., Kaplan, O., Ruiz-Cabello, J., and Collier, S. A History of Biological Magnetic Resonance. In: J. W. Emsley and J. Feeney (eds.), Progr. Magn. Reson. Spect. (50th ann. ed. of discovery of NMR), Vol. 28, pp. 53-86. London: Elsevier, 1995.

  53. Mercola, D., and Cohen, J. S. Antisense approaches to cancer gene therapy, Cancer Gene Therapy. 2: 47-59, 1995.

  54. Mardor, Y., and Cohen, J. S. Primer on Magnetic Resonance Methods: MRI and MRS, in Encyclopedia of Cancer, Vol. 2. San Diego: Academic Press, 2002.

  55. Cohen J.S. (co-ed) Encyclopedia of Cancer, Vol. 2. San Diego: Academic Press, 2002

  56. Cohen, J.S. Biomedical Applications of Diffusion Weighted NMR Techniques. Israel J. Chem., 43: 81-90, 2003.

  57. Cohen, J.S. History of Research on Antisense Oligonucleotide Analogs, Substantia (Intl. J. Hist. Chem.), 5: 9-25, 2021.

  58. Cohen, J.S. The Revolution in Science in America 1900-1950, Substantia (Intl. J. Hist. Chem.), 5: 83-93, 2021.

  59. Daly, P.F., and Cohen, J.S. History of research on phospholipid metabolism and applications to the detection, diagnosis, and treatment of cancer, , Substantia (Intl. J. Hist. Chem.), 6: 49-76, 2022.

RESEARCH PUBLICATIONS:

 

1. Blackburn, G. M., Cohen, J. S., and Todd, L. Cylic Phosphate and Phosphate Triesters a 31P NMR Study, Tetrahedron Lett. No. 39: 2873, 1964.

2.  Cohen, J. S. 31P and 1H NMR Studies of Tetramethoxyphosphonium Hexachlorantimonate and Related Compounds, Tetrahedron Lett. No. 39: 3491, 1965.

3.  Blackburn, G. M., Cohen, J. S., and Todd, L. The Synthesis of Dialkyl Phosphates from Monoalkly Phosphonates - Direct Oxidative Esterification, J. Chem. Soc. (C). 239:1966.

4.  Cohen, J. S., and Lapidot, A. Reduction Studies with Naturally Occurring Quinones and their Phosphate Derivatives with Reference to Oxidative Phosphorylation, J. Biol. Chem. 241: 4060, 1966.

5.  Cohen, J. S. Proton and Phosphorus-31 Nuclear Magnetic Resonance Studies of Tetraalkoxyphosphonium Hexachlorantimonates and Related Compounds, J. Am. Chem. Soc. 89: 2543, 1967.

6.   Cohen, J. S., and Lapidot, A. Proof of the Imidoyl Phosphate Intermediate on Oxidative Phosphorylation in 18O-N,N-Dimethyl-formamide Solution, J. Chem. Soc. (C) 2320, 1967.

7.   Meadows, D. H., Markley, J. L., Cohen, J. S., and Jardetsky, O. Nuclear Magnetic Resonance Studies of the Structure and Binding Sites of Enzymes, I. Histidine Residues, Proc. Natl. Acad. Sci. USA. 58: 1307, 1967.

8.  Cohen, J. S. Imidazole-Phosphate Interaction in Dimethyl Sulphoxide with Reference to Ribonuclease Inhibitor Binding, Biochem. Biophys. Res. Comm. 33: 465, 1968.

9.  Cohen, J. S., and Jardetsky, O. Nuclear Magnetic Resonance Studies of the Structure and Binding Sites of Enzymes, II. Spectral Assignments and Inhibitor Binding in Hen-Egg White Lysozyme, Proc. Natl. Acad. Sci. USA. 60: 93, 1968.

10. Cohen, J. S. Investigations of the Binding of Small Molecules to Protein Using Information from Nuclear Magnetic Resonance, J. Clin. Pharmacol. 9: 69, 1969.

11. Cohen, J. S. Proton Magnetic Resonance Studies of Human Lysozyme, Nature. 223:, 1969.

12. Horsley, W., Sternlicht, H., and Cohen, J. S. Carbon-13 Nuclear Magnetic Resonance Studies of Carbon-13 Enriched Amino Acids, Biochem. Biophys. Res. Commun. 37: 47, 1969.

13.  Roberts, G. C. K., Dennis, E. A., Meadows, D. H., Cohen, J. S., and Jardetzky, O. The Mechanism of Action of Ribonuclease, Proc. Natl. Acad. Sci. USA. 62: 1151-8, 1969.

14.  Cohen, J. S., Horsley, W., and Sternlich, H. The Isolation of Carbon-13 Enriched Amino Acids, Biochim. Biophys. Acta. 222: 521, 1970.

15.  Cohen, J. S., Shrager, R. L., McNeel, M., and Schecter, A. N. On-line Computer-Assisted Analysis of 220 MHz Data of Protein Imidazole Resonances, Biochem. Biophys. Res. Commun. 40: 144, 1970.

16.  Cohen, J. S., and Putter, I. The Isolation of Deuterated Amino Acids, Biochim. Biophys. Acta. 222: 525, 1970.

17.  Cohen, J. S., , Shrager, R., McNeel, M., and Schecter, A.N.  Proton Magnetic Resonance Studies of the Histidine Residues of S. Nuclease, Nature. 228: 642, 1970.

18.  Horsley, W., Sternlicht, H., and Cohen, J. S. Carbon-13 Magnetic Resonance Studies of Amino Acids and Peptides, J. Am. Chem. Soc. 92: 680, 1970.

19.  Vanden Heuval, W. J. A., and Cohen, J. S. Gas-liquid Chromatography Mass Spectrometry of Carbon-13 Enriched Amino Acids as Trimethyl Derivatives, Biochim. Biophys. Acta. 208: 251, 1970.

20.  Vanden Heuval, W. J. A., Smith, J. L., Putter, L., and Cohen, J. S.  Gas-liquid Chromatography Mass Spectrometry of Deuterium-Containing Amino Acids as Trimethylsiyl Derivatives, J. Chromatog. 50: 405-12, 1970.

21.  Vanden Heuval, W. J. A., Smith, J. L., and Cohen, J. S. Gas-liquid Chromatography and Mass Spectrometry of Carbon-13 Enriched and Deuterated Amino Acids as Trimethylsilyl Derivatives, J. Chromatogr. Sci. 8: 567, 1970.

22.  Blackburn, G. M., Cohen, J. S., and Weatherall, I. Phosphorus-31 NMR Studies of Cyclic Derivatives of Phosphorus Oxy-Acids, Tetrahedron. 27: 2903-12, 1971.

23.  Cohen, J. S. Proton Magnetic Resonance Studies of Oligo-peptides Containing Aromatic Residues,  Biochim. Biophys. Acta. 229: 603, 1971.

24.  Cohen, J. S., Feil, M., and Chaiken, I. Proton Magnetic Resonance Studies of the Tyrosine Residues of Staphylococcal Nuclease Using (3,5-d) Tyrosine, Biochim. Biophys. Acta. 236: 468, 1971.

25. Epstein, H., Schechter, A. N., and Cohen, J. S. Folding of Staphylococcal Nuclease: Magnetic Resonance and Fluorescence Studies of Individual Residues, Proc. Natl. Acad. Sci. USA. 68: 2042, 1971.

26. Freedman, M., Cohen, J. S., and Chaiken, I. Carbon-13 Fourier Transform Nuclear Magnetic Resonance Studies of Peptides, Biochem. Biophys. Res. Commun. 42: 1148, 1971.

27.  Sachs, D. H., Schecter, A. N., and Cohen, J. S. Nuclear Magnetic Resonance Titration Curves of Histidine Ring Protons, I. Neighboring Charged Groups, J. Biol. Chem. 246: 6576, 1971.

28. Vanden Heuval, W. J. A., Arison, B. H., and Cohen, J. S. Combined Gas-liquid Chromatography Mass Spectrometry Study of the Bromine Oxidation of Synkavit in 18O-Dimethylformamide, J. Chromatog. 59: 169, 1971.

29. Cohen, J. S., Hagenmaier, H. P., Pollard, H., and Schecter, A. N. Proton Magnetic Resonance Study of the Histidine Residues of Sperm Whale and Horse Myoglobins, J. Mol. Biol. 71: 513, 1972.

30.  Cohen, J. S., Yim, C. T., Kandel, M., Gornall, A. G., Kandell, S. J., and Freedman, M. H. Studies of the Histidine Residues of Carbonic Anhydrases Using High Field Proton Magnetic Resonance, Biochemistry. 11: 327, 1972.

31. Cohen, P., Griffin, J. H., Camier, M., Caizergues, M., Fromageot, P., and Cohen, J. S. Hormonal Interactions at the Molecular Level: High Resolution PMR Study of Bovine Neurophysins and Their Interactions with Oxytocin, FEBS Lett. 25: 282, 1972.

32.  Schecter, A. N., Sachs, D. H., Heller, S. R., Shrager, R. I., and Cohen, J. S. NMR Titration Curves of Histidine Ring Protons, III. Ribonuclease, J. Mol. Biol. 71: 39, 1972.

33. Shrager, R., Cohen, J. S., Sachs, D. H., and Schecter, A. N. Nuclear Magnetic Resonance Titration Curves of Histidine Ring Protons, II. Mathematical Models for Interacting Groups, Biochemistry. 11: 541, 1972.

34. Chaiken, I. M., Freedman, M. H., Lyerla, J. R., and Cohen, J. S. Preparation and Properties of 19F and Enriched 13C-Labeled Semisynthetic Ribonuclease-S' Analogues, J. Biol. Chem. 248: 884, 1973.

35. Cohen, J. S., Grffin. J.H., and Schecter, A. N. NMR Titration Curves of Histidine Ring Protons, IV. The Effects of Phosphate and Sulphate on Ribonuclease, J. Biol. Chem. 248: 4305, 1973.

36. Feldmann, R. J., Bacon, C. R. T., and Cohen, J. S. Versatile Interactive Graphics Display System for Molecular Modelling by Computer, Nature. 244: 113, 1973.

37. Freedman, M. H., Lyerla, J. R., Chaiken, I. M., and Cohen, J. S. Carbon-13 Fourier Transform Nuclear Magnetic Resonance Studies of Selected Amino Acids, Peptides and Proteins, Eur. J. Biochem. 32: 215, 1973.

38. Griffin, J., Cohen, J. S., and Schecter, A. N. Assignment of an Exchangeable Low-Field NH Resonance of Ribonuclease A to the Active Site Histidine-119, Biochemistry. 12: 2096, 1973.

39. Griffin, J. H., Schecter, A. N.,  and. Cohen, J. S. Nuclear Magnetic Resonance Studies of a Ribonuclease-Dincucleoside Phosphonate Complex and Their Implications for the Mechanism of the Enzyme, Ann. NY Acad. Sci. 222: 693, 1973.

40. Alazard, R., Cohen, P., Cohen, J. S., and Griffin, J. H. Interactions of Bovine Neurophysin II with Oxytoxin and (8-Lysine) Vasopressin. High Resolution Proton Nuclear Magnetic Resonance Spectroscopy Studies, J. Biol. Chem. 249: 6895, 1974.

41. Chaiken, I. M., Cohen, J. S., and Sokolski, E. Microenvironment of His 12 in Ribonuclease S as Detected by 13C NMR, J. Am. Chem. Soc. 96: 4703, 1974.

42. Cohen, J. S., Fisher, W., and Schecter, A. N. Spectroscopic Studies on the Conformation of Cytochrome c and Apocytochrome, J. Biol. Chem. 249: 1113, 1974.

43. Cohen, J. S., and Hayes, M B. Titration Curves of Histidine Ring Protons, V. Comparative Study of Cytochrome c from Three Species and the Assignment of Individual Proton Resonances, J. Biol. Chem. 249: 5472, 1974.

44.  Quirt, A. R., Lyerla, J. R., Peat, I. R., Cohen, J. S., Reynolds, W. R., and Freedman, M. H. Carbon-13 NMR Titration Shifts in Amino Acids, Nature. 96: 570, 1974.

45. Wasylishen, R., and Cohen, J. S. Spin Lattice Relaxation Times of Imidazole Protons and Their Relevance to NMR Studies of Proteins. Nature. 249: 847, 1974.

46. Cohen, J. S., Bradley, R. B., and Clem, T. R. The pH- Dependence of the 13C Spin-Lattice Relaxation Rate of the Carboxyl Carbon of Acetic Acid, J. Am. Chem. Soc. 97: 908, 1975.

47. Cohen, J. S., and Shindo, H. NMR Titration Curves of Histidine Ring Protons VIII. Conformational Change Affecting Three of the Histidine Residues of Ribonuclease, J. Biol. Chem. 250: 8874, 1975.

48. Cohen, P., Camier, M., Alazard, R., Cohen, J. S., and Griffin, J. Studies of Bovine Neurophysin-Neurophypophyseal Hormone Interactions, Ann. NY Acad. Sci. 248: 463, 1975.

49. Griffin, J. H., Cohen, J. S., and Cohen, P. Proton Magnetic Resonance Studies of Complex Formation Between Bovine Neurophysins and Oxytocin, J. Pharm. Sci. 64: 507, 1975.

50. Hayes, M. B., Hagenmaier, H., and Cohen, J. S. NMR Titration Curves of Histidine Ring Protons. VII. Human Metmyoglobin and the Effects of Azide on Human, Horse and Sperm Whale Metmyoglobins, J. Biol. Chem. 250:, 1975.

51. Westmoreland, D. Matthews, C. R.,, Hayes, M. B., and Cohen, J. S. NMR Titration Curves of Histidine Ring Protons. VI. Effect of Temperature on Ribonuclease A, J. Biol. Chem. 250: 7456, 1975.

52. Yeh, H. C., Kirk, K. L., Cohen, L. A., and Cohen, J. S. 19F and 1H Nuclear Magnetic Resonance Studies of Ring-Fluorinated Imidazoles and Histidines, J. Chem Soc., Perkin II 928, 1975.

53. Matsuura, S., Niu, C., and Cohen, J. S. Pyridium Polyhydrogen Fluoride, A Deprotecting Reagent in Peptide Chemistry, Chem. Comm. 451, 1976.

54. Shindo, H., and Cohen, J. S. NMR Titration Curves of Histidine Ring Protons X. Ribonuclease S-Peptide and S-Protein, J. Biol. Chem. 251: 2648, 1976.

55. Shindo, H., and Cohen, J. S. Observation of Individual Carboxyl Groups in Hen Egg White Lysozyme Using High Field Carbon-13 Nuclear Magnetic Resonance, Proc. Natl. Acad. Sci. USA. 73: 1979, 1976.

56. Shindo, H., Hayes, M. B., and Cohen, J. S. NMR Titration Curves of Histidine Ring Protons IX. A Direct Assignment of the Resonances of the Active Site Histidine Residues of Ribonuclease, J. Biol. Chem. 251: 2644, 1976.

57. Egan, W., Liu, T.-Y., Dorow, S., Cohen, J. S., Robbins, J. D., Gotschlich, E. C., and Robbins, J. B. Structural Studies of the Sialic Acid Polysaccharide Antigen of E. Coli Strain Bos-12, Biochemistry. 16: 3687, 1977.

58.  Niu, C., Shindo, H., Cross, M., and Cohen, J. S. Characterization of the Acetyl-Chromotrpysin Intermediate by 13C NMR Spectroscopy Intermediate by 13C NMR Spectroscopy, J. Am. Chem. Soc. 99: 3161, 1977.

59.  Shindo, H., Cohen, J. S., and Rupley, J. A. Self-Association of Hen Egg White Lysozyme As Studied by Nuclear Magnetic Resonance, Biochemistry. 16: 3879, 1977.

60. Wasylishen, R. E., and Cohen, J. S. Influence of Copper(II) on Proton Nuclear Relaxation Rates of Poly-L-Histidine, J. Am. Chem. Soc. 99: 2480, 1977.

61. Egan, W., Shindo, H., and Cohen, J. S. On the Tyrosine Residues of Ribonuclease, J. Biol. Chem. 253: 16, 1978.

62. Schejter, A., Lanir, A., Vig, I., and Cohen, J. S. Direct Observation of the Methionine Residues of Cytochrome c by Carbon-13 NMR Spectroscopy, J. Biol. Chem. 253: 3768, 1978.

63. Shindo, H., Egan, W., and Cohen, J. S. Studies of Individual Carboxyl Groups in Proteins by Carbon-13 NMR Spectroscopy, J. Biol. Chem. 253: 6751, 1978.

64. Ader, R., and Cohen, J. S. Relaxation Time Measurements of Bulk Water in Packed Mammalian Density Dependent Cells Grown in Culture, J. Mag. Res. 34: 349, 1979.

65.  Granot, J., Elgavish, G., and Cohen, J. S. Phosphorus-31 Relaxation Times of Inorganic Phosphate and Nucleotides in Aqueous Solution, J. Magn. Res. 33: 569, 1979.

66.  Niu, C., Bertrand, R., Shindo, H., and Cohen, J. S. Cross-Peptide Bond 13C - 15N Coupling Constants by 13C and J Cross-Polarization 15N NMR, J. Biochem. Biophys. Methods. 1: 135, 1979.

67.  Niu, C., Matsuura, S., Shindo, H., and Cohen, J. S. Specific Peptide-Protein Interactions in the Ribonuclease S' System Studied by 13C Nuclear Magnetic Resonance Spectroscopy with Selectively 13C Enriched Peptides, J. Biol. Chem. 254: 3788, 1979.

68. Ohms, J. P., Hagenmaier, H., Hayes, M. B., and Cohen, J. S. The Near-heme Histidine Residues of Deoxy- and Oxymyoglobins, Biochemistry. 18: 1599, 1979.

69. Pollard, H., Shindo, H., Cruetz, C., Pazoles, C., and Cohen, J. S. The State of ATP and the Quantitation of Intragranular pH in Adrenergic Chromaffin Granules by 31P Nuclear Magnetic Resonance Spectroscopy, J. Biol. Chem. 254: 1170, 1979.

70.  Rosen, P., Pecht, L., and Cohen, J. S. Monitoring the Carbohydrate of the Fc Fragment of Human IgG by 13C NMR Spectroscopy, Mol. Immunol. 16: 435, 1979.

71.  Shindo, H., Matsuura, S., and Cohen, J. S. Conformation of Ribonuclease S-Protein, Experientia. 35: 1284, 1979.

72.  Shindo, H., Simpson, R., and Cohen, J. S. An Alternating Conformation Characterizes the Phosphodiester Backbone of Poly(dAdT) in Solution, J. Biol. Chem. 254: 8125, 1979.

73. Wooten, J., and Cohen, J. S. Protein Mobility and Self-Association by Deuterium NMR, Biochemistry. 18: 4188, 1979.

74.  Cohen, J. S., Yariv, J., Kalb (Gilboa), A. J., Jacobson, L., and Schecter, Y. Carbon-13 NMR Analysis of Methionine Sulphoxide in Protein, J. Biochem. Biophys. Methods. 1: 145, 1979.

75.   Niu, C., Shindo, H., Matsuura, S., and Cohen, J. S. Direct Observation of Peptide Exchange by Stable Isotope Enrichment, J. Biol. Chem. 255: 2036, 1980.

76.  Shindo, H., McGhee, J., and Cohen, J. S. 31P NMR Studies of DNA in Nucleosome Core Particles, Biopolymers. 19: 523, 1980.

77.  Chen, C.-W., Cohen, J. S., and Zador, A. Convenient Continuous Sonication Method for the Preparation of Medium-Sized Polydeoxynucleotides, J. Biochem. Biophys. Methods. 5:, 1981.

78.  Cohen, J. S., Wooten, J. B., and Chatterjee, C. L. Characterization of Alternating DNA Conformations in 31P NMR Spectroscopy``, Biochemistry. 20: 3049, 1981.

79.   Jacobsen, L., and Cohen, J. S. Improved Technique for the Investigation of Cell Metabolism, Biosci. Rep. 1: 141, 1981.

80. Wooten, J. B., Cohen, J. S., Vig, I., and Schejter, A. The pH-Induced Conformational Transitions of Ferricytochrome c: a 13C and 1H NMR Study, Biochemistry. 20: 5394, 1981.

81.  Zweier, J., Wooten, J. B., and Cohen, J. S. Studies of Anion Binding by Transferrin using 13C NMR Spectroscopy, Biochemistry. 20: 3505, 1981.

82.  Chen, C.-W., Cohen, J. S., and Behe, M. The B to Z Transition of Double-Stranded Poly(deoxyguanyl deoxycytidine) in Solution, Biochemistry. 22: 2136-2142, 1983.

83.  Chen, C.-W., and Cohen, J. S. Salt and Sequence Dependence of the Secondary Structure of DNA in Solution by 31P NMR Spectroscopy, Biopolymers. 22: 879-893, 1983.

84.  Chen, C.-W., Knop, R. H., and Cohen, J. S. Adriamycin Inhibits the B to Z Transition of Poly(dGm5dc).poly(dGm5dC), Biochemistry. 22: 5468-5471, 1983.

85. Foxall, D. L., and Cohen, J. S. NMR Studies of Perfused Cells, J. Mag. Res. 52: 346-349, 1983.

86.  Foxall, D. L., Cohen, J. S., and Tschudin, R. G. Selective Observation of 13C Enriched Metabolites by 1H NMR, J. Magn. Res. 51: 330-334, 1983.

87. Navon, G., Burrows, H., and Cohen, J. S. Differences in Metabolite Levels Upon Differentiation of Intact Neuroblastoma/Glioma Cells Observed by Proton NMR Spectroscopy, FEBS Lett. 162: 320-323, 1983.

88.  Chen, C.-W., Cohen, J. S., Myers, C. E., and Sohn, M. Paramagnetic Metalloporphyrins as Potential Contrast Agents in NMR Imaging, FEBS Lett. 168: 70, 1984.

89.  Cohen, J. S., Chen, C. W., and Bax, A. Selective Observation of Phosphate Ester Protons by 1H(31P) Spin Echo Different Spectroscopy,  J. Magn. Res. 59: 181-187, 1984.

90. Foxall, D. L., Cohen, J. S., and Mitchell, J. B. Continuous Perfusion of Mammalian Cells Embedded in Agarose Gel Threads, Exp. Cell Res. 154: 521-529, 1984.

91. Howard, F. B., Chen, C.-W., Cohen, J. S., and Miles, H. T. Poly(d2NH2A.dT); Effects of 2-Amino Substituent on the B to Z Transition, Biochem. Biophys. Res. Commun. 118: 848-853, 1984.

92.  Hughes, L. T., Cohen, J. S., Szabo, A., Niu, C., and Matsuura, S. 13C NMR Studies of the Molecular Dynamics of Selectively 13C Enriched Ribonuclease Complexes, Biochemistry. 23: 4390-4394, 1984.

93.  Knop, R., Chen, C.-W., Mitchell, J. B., Russo, A., McPherson, S., and Cohen, J. S. Metabolic Studies of Mammalian Cells by 31P NMR Using a Continuous Perfusion Technique, Biochim. Biophys. Acta. 894: 275-284, 1984.

94.  Borah, B., Chen, C., Egan, W., Miller, M., Wlodawer, A., and Cohen, J. S. NMR and Neutron Diffraction Studies of the Complex of RNase with Uridine Vanadate, a Transition State Analog, Biochemistry. 24: 2058-2067, 1985.

95.  Borah, B., Cohen, J. S., and Bax, A. Conformation of Double Stranded Polydeoxynucleotides in Solution by Proton Two-Dimensional Nuclear Overhauser Enhancement Spectroscopy, Biopolymers. 24: 747-765, 1985.

96.  Borah, B., Cohen, J. S., Howard, F. B., and Miles, H. T. Poly(d2NH2A.dT): Characterization of the High Salt Form by Two-Dimensional NMR Spectroscopy, Biochemistry. 24: 7456-7462, 1985.

97.  Borah, B., Roy, S., Zon, G., and Cohen, J. S. Unique Pyrimidine 2D-COSY Aromatic Cross-Peaks as Monitors of Pyrimidine Environments and Mobility in Oligo- and Poly-nucleotides, Biochem. Biophys. Res. Comm. 133: 380-388, 1985.

98.  Knop, R. H., Chen, C. W., Mitchell, J. B., Russo, A., McPherson, S., and Cohen, J. S. Adaptive Cellular Response to Hyperthermia: 31P-NMR Studies, Biochim. Biophys. Acta. 845: 171-177, 1985.

99.  Borah, B., Howard, F. B., Miles, T. M., and Cohen, J. S. Conversions of Poly(d2NH2A-dXU) from B to A Forms in High Salt an NMR and CD Study, Biochemistry. 25: 7464-7470, 1986.

100. Cohen, J. S., Lyon, R. C., Chen, R. C., Faustino, P. J., Batist, G., Shoemaker, M., Rubalcaba, E., and Cowan, K. H. Differences in phosphate metabolite levels in drug-sensitive and -resistant human breast cancer cell lines determined by 31P magnetic resonance spectroscopy, Cancer Res. 46: 4087-4090, 1986.

101. Lyon, R. C., Faustino, P. J., and Cohen, J. S. A Perfusion Technique for 13C NMR Studies of the Metabolism of 13C-Labeled Substrates by Mammalian Cells, Mag. Reson. Med. 3: 663-672, 1986.

102. Patronas, N. J., Cohen, J. S., Knop, R. H., Dwyer, A. J., Colcher, D., Lundy, J., Mornex, F., Hambright, P., Sohn, M., and Myers, C. E. Metalloporphyrin Contrast Agents for Magnetic Resonance Imaging of Human Tumors in Mice, Cancer Treat. Rep. 70: 390, 1986.

103.Roy, S., Hiyama, Y., Torchia, D., and Cohen, J. S. New Enzymatic Synthesis of 2'-deoxynucleoside-2',2'-d2 and the Determination of the Sugar Ring Flexibility by Steady-State Deuterium, J. Am. Chem. Soc. 108: 1675-1678, 1986.

104. Roy, S., Weinstein, S., Borah, B., Nichol, J., E., A., Sussman, J. L., Miller, M., Shindo, H., and Cohen, J. S. Mechanism of Oligonucleotide Loop Formation in Solution, Biochemistry. 25: 7417-74231, 1986.

105. Cohen, J. S., and Lyon, R. C. Multinuclear NMR Study of the Metabolism of Drug-Sensitive and Drug-Resistant Human Breast Cancer Cells, Ann. NY Acad. Sci. 508: 216-228, 1987.

106. Daly, P. F., Lyon, R. C., Faustino, P. J., and Cohen, J. S. Phospholipid metabolism in cancer cells monitored by 31P NMR spectroscopy, J. Biol. Chem. 262: 14875-14878, 1987.

107. Hambright, P., Turner, A., Cohen, J. S., Lyon, R. C., Katz, P., and Ademeyo, A. N. An Iron(III) Porphyrin that Exhibits Minimal Dimerization in Aqueous Solution, Inorg. Chim. Acta. 128: L11, 1987.

108. Knop, R. H., Carney, D. N., Chen, C.-W., Cohen, J. S., and Minna, J. D. Levels of High Energy Phosphates in Human Lung Cancer Cell Lines by 31P Nuclear Magnetic Resonance Spectroscopy, Cancer Res. 47: 3357-3359, 1987.

109. Lyon, R. C., Faustino, P. J., Cohen, J. S., Katz, A., Mornex, F., Colcher, D., Baglin, C., Koenig, S. H., and Hambright, P. Tissue Distribution and Stability of Metalloporphyrin, Mag. Res. Med. 4: 24-33, 1987.

110. Matsukura, M., Shinozuka, K., Zon, G., Mitsuya, H., Reitz, M., Cohen, J. S., and Broder, S. Phosphorothioate Analogs of Oligodeoxynucleotides as Novel Inhibitors of Replication and Cytopathic Effect of Human Immunodeficiency Virus, Proc. Natl. Acad Sci. USA. 84: 7706-7710, 1987.

111. Megnin, F., Faustino, P. J., Lyon, R. C., Lelkes, P. I., and Cohen, J. S. On the Mechanism of Selective Retention of Porphyrins and Metalloporphyrins by Cancer Cells, Biochim. Biophys. Acta. 929: 173-181, 1987.

112. Miller, M., Kirchoff, W., Shwarz, F., Appella, E., Chiu, Y. H., Cohen, J. S., and Sussman, J. L. Conformational Transitions of Synthetic DNA Sequences with Inserted Bases Related to the Dodecamer d(CGCGAATTCGCG), Nucl. Acids Res. 15: 3877-3890, 1987.

113. Roy, S., Borah, B., and Cohen, J. S. Conformation of the Oligonucleotide a(AAAAAATTTTTT)2 by 2D-NOESY and Its Relevance to Poly(dA).poly(dT), Biopolymers. 26: 525-536, 1987.

114. Roy, S., Sklenar, V., Appella, E., and Cohen, J. S. Conformational Pertubation Due to an Extra Adenosine in a Self-Complementary Oligodeoxynucleotide Duplex, Biopolymers. 26: 2041-2052, 1987.

115. Shindo, H., Hiyama, Y., Roy, S., Cohen, J. S., and Torchia, D. A. Deuterium NMR Studies of Oriented DNA Fibers, Bull. Chem. Soc. Japan. 60: 1631-1640, 1987.

116. Daly, P. F., Lyon, R. C., Straka, E. J., and Cohen, J. S. 31P NMR spectroscopy of human cancer cells proliferating in a basement membrane gel, FASEB J. 2: 2596-2604, 1988.

117. Loke, S. L., Zhang, X. H., Stein, C. A., Avigan, M., Cohen, J. S., and Neckers, L. M. Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematapoietic cells in culture by liposome fusion, Curr. Top. Microbiol. Immunol. 141: 282-289, 1988.

118.     Lyon, R. C., Cohen, J. C., Faustino, P. J., Megnin, F., and Myers, C. E. Glucose Metabolism in Drug-Sensitive and Drug-Resistant Human Breast Cancer Cells Monitored by Magnetic Resonance Spectroscopy, Cancer Res. 48: 870-877, 1988.

119. Lyon, R. C., Tschudin, R. G., and Cohen, J. S. A Versatile Multinuclear Probe Designed for In Vivo NMR Spectroscopy: Applications to Subcutaneous Human Tumors in Mice, Mag. Res. Med. 6: 1-14, 1988.

120. Matsukura, M., Zon, G., Shinozuka, K., Stein, C. A., Mitsuya, M., Cohen, J. S., and Broder, S. A. Synthesis of phosphorothioate Analogs of Oligodeoxynucleotides and their Anti-viral Activity Against HIV, Gene. 72: 343-347, 1988.

121. Stein, C. A., Mori, K., Loke, S. L., Subasinghe, C., Shinozuka, K., Cohen, J. S., and Neckers, L. M. Phosphorothioate and Normal Oligodeoxynucleotides with 5'-linked Acridine: Characterization Preliminary Kinetics of Cellular Uptake, Gene. 72: 333-341, 1988.

122. Stein, C. A., Subasinghe, C., Shinozuka, K., and Cohen, J. S. Physicochemical Properties of Phosphorothioate Oligodeoxynucleotides, Nucl. Acids Res. 16: 3209-3221, 1988.

123. Cazenave, C., Stein, C. A., Loreau, N., Thuong, N. T., Neckers, L. M., Subasinghe, C., Helene, C., Cohen, J. S., and Toulme, J. J. Comparative Inhibition of Rabbit Globin mRNA Translation by Modified Antisense Oligodeoxynucleotides, Nucl. Acids Res. 17: 4255-4273, 1989.

124. Gao, W., Stein, C. A., Cohen, J. S., Dutschman, G. E., and Cheng, Y.-C. Effect of phosphorothioates homo-oligonucleotides on herpes simplex virus type-2 induced DNA polymerase, J. Biol. Chem. 264: 11521-11526, 1989.

125. Hiyama, Y., Roy, S., Cohen, J. S., and Torchia, D. A. Solid-state 2H NMR study of thymidine base rigidity and ribose ring flexibility in deoxynucleosides, J. Am. Chem. Soc. 111: 8609-8613, 1989.

126. Kaplan, O., Aebersold, P., and Cohen, J. S. Metabolism of peripheral lymphocytes, interleukin-2-activated lymphocytes and tumor-infiltrating lymphocytes from 31P NMR studies, FEBS Lett. 258: 55-58, 1989.

127. Loke, S. L., Stein, C. A., Zhang, X. H., Mori, K., Nakanishi, M., Subasinghe, C., Cohen, J. S., and Neckers, L. M. Characterization of oligodeoxynucleotide transport into living cells, Proc. Natl. Acad. Sci. USA. 86: 3474-3478, 1989.

128. Majumdar, C., Stein, C. A., Cohen, J. S., Broder, S. A., and Wilson, S. Reverse Transcriptase Stepwise Mechanism: Phosphorothioate Oligodeoxynucleotides as Primer, Biochemistry. 28: 1340-1346, 1989.

129. Matsukura, M., Zon, G., Shinozuka, K., Roberts-Guroff, M., Stein, C. A., Mitsuya, H., Wong-Staal, F., Cohen, J. S., and Broder, S. A. Regulation of Viral Expression of HIV in vitro by Antisense Phosphorothioate Oligodeoxynucleotide against rev, Proc. Natl. Acad. Sci. USA. 86: 4244-4248, 1989.

130.     Mori, K., Boizeau, C., Cazenave, C., Matsukura, M., Subasinghe, C., Cohen, J. S., Toulme, J. J., and Stein, C. A. Phosphoroselenoate oligodeoxynucleotides: synthesis, physico-chemical characterization, anti-sense inhibitory properties and anti-HIV activity, Nucl. Acids. Res. 17:8207-19, 1989.

131. Mori, K., Subasinghe, C., and Cohen, J. S. Oligodeoxynucleotide analogs with 5'-linked anthraquinone, FEBS Lett. 249: 213-218, 1989.

132. Mori, K., Subasinghe, C., Stein, C. A., and Cohen, J. S. Synthesis and properties of novel 5'-linked oligodeoxynucleotides, Nucleosides Nucleotides. 8: 649-657, 1989.

133. Navon, G., Lyon, R. C., Kaplan, O., and Cohen, J. S. Monitoring the transport of 2-deoxy-D-glucose in tumor cells in vivo and in vitro by 13C nuclear magnetic resonance spectrscopy, FEBS Lett. 247: 86-90, 1989.

134.  Stein, C. A., Matsukura, M., Subasinghe, C., Broder, S., and Cohen, J. S. Phosphorothioate oligodeoxynucleotides are potent non-specific inhibitors of de novo infection by HIV, AIDS Res. Hum. Retroviruses. 5: 639-646, 1989.

135. van Zijl, P. C. M., Moonen, C. W. T., Alger, J. R., Cohen, J. S., and Chesnick, S. A. A high field localized proton spectroscopy in small volumes: improved localization and shimming using shielded strong gradients, Mag. Res. Med. 10: 256-265, 1989.

136. Daly, P. F., Zugmaier, G., Sandler, D., Carpen, M., Myers, C. E., and Cohen, J. S. Regulation of the Cytidine Phospholipid Pathways in Human Cancer Cells and Effects of Ara-C: a Non-Invasive 31P NMR Study, Cancer Res. 50: 552-557, 1990.

137.  Gao, W., Jaroszewski, J. W., Cohen, J. S., and Cheng, Y.-C. Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine,  J. Biol. Chem. 33: 20172-20178, 1990.

138.  Gao, W.-Y., Hanes, R. N., Vasquez-Padua, M. A., Stein, C. A., Cohen, J. S., and Cheng, Y.-C. Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides, Antimicrob. Agents Chemother. 34: 808-812, 1990.

139. Jaroszewski, J., Kaplan, O., and Cohen, J. S. Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P NMR and toxicity studies, Cancer Res. 50: 6936-6943, 1990.

140. Jaroszewski, J. W., Kaplan, O., Syi, J.-L., Sehested, M., Faustino, P. J., and Cohen, J. S. Concerning antisense inhibition of the multidrug resistance gene, Cancer Commun. 2: 287-294, 1990.

141. Kaplan, O., Jaroszewski, J. W., Faustino, P. J., Zugmaier, G., Ennis, B. W., Lippman, M., and Cohen, J. S. Toxicity and effects of epidermal growth factor on glucose metabolism of MDA-468 human breast cancer cells, J. Biol. Chem. 265: 13641-13649, 1990.

142. Kaplan, O., Navon, G., Lyon, R. C., Faustino, P. J., Straka, E. J., and Cohen, J. S. Effects of 2-deoxyglucose on drug-sensitive and drug-resistant breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism, Cancer Res. 50: 544-551, 1990.

143. Kaplan, O., van Zijl, P. C. M., and Cohen, J. S. Information from combined 1H and 31P NMR studies of cell extracts: Differences between drug-sensitive and drug-resistant MCF-7 human breast cancer cells, Biochem. Biophys. Res. Comm. 169: 383-390, 1990.

144. Rayner, B., Matsukura, M., Morvan, F., Cohen, J.S., Imbach, J.-L Activite anti-VIH in vitro d'oligodesoxynucleotides phosphorothioates d'anomerie alpha, C.R. Acad. Sci. Paris. 310: 61-64, 1990.

145. Reed, J. C., Stein, C. A., Subasinghe, C. A., Haldar, S., Croce, C. M., Yum, S., and Cohen, J. S. Antisense-mediated inhibition of BCL2 proto-oncogene expression and leukemic cell growth; comparisons of phosphorothioate oligonucleotides, Cancer Res. 50: 6565-6570, 1990.

146. Stein, C. A., Iversen, P. L., Subasinghe, C., Cohen, J. S., Stec, W. J., and Zon, G. Preparation of 35S-labeled  phosphorothioate oligodeoxynucleotides by use of phosphonate chemistry, Anal. Biochem. 188: 11-16, 1990.

147. van Zijl, P. C. M., Moonen, C. T. W., Gillen, J., Daly, P. F., Frank, J. F., DeLaney, T. F., Kaplan, O., and Cohen, J. S. Proton magnetic resonance spectroscopy of small regions (1 mL) localized inside human tumors. A clinical feasibility study. NMR Biomed. 3: 227-232, 1990.

148. van Zijl, P. C. M., Place, D. A., Cohen, J. S., Faustino, P. J., Lyon, R. C., and Patronas, N. J. Metalloporphyrin magnetic resonance contrast agents: feasibility of tumor-specific MRI, Invest. Radiol. 25: S69-S70, 1990.

149.  van Zijl, P. C. M., Moonen, C. T. W., Faustino, P. J., Pekar, J., Kaplan, P., and Cohen, J. S. Complete separation of intracellular and extracellular information in NMR spectra by diffusion weighting, Proc. Natl. Acad. Sci. USA. 88: 3228-3232, 1991.

150. Ghosh, M., Ghosh, M., and Cohen, J. S. Oligodeoxynucleotide analogs as informational drugs to regulate translation, Nucl. Acids Res. Symp. Series 24: 139-142, 1991.

151. Kaplan, O., and Cohen, J. S. Lymphocyte activation and phospholipid pathways: 31P magnetic resonance studies, J. Biol. Chem. 265: 20712-20718, 1991.

152. Kaplan, O., Jaroszewski, J. W., Clarke, R., Fairchild, C. R., Schoenlien, P., S., G., Gottesman, M. M., and Cohen, J. S. The multidrug resistance phenotype: 31P NMR characterization and 2-deoxyglucose toxicity, Cancer Res. 51: 1638-1644, 1991.

153. Berghmans, K., Ruiz-Cabello, J., Simpkins, H. J., Andrews, P. A., and Cohen, J. S. Increase in the ATP signal after treatment with cisplatin in two different cell lines studied by 31P NMR spectroscopy, Biochem. Biophys. Res. Comm. 183: 114-120, 1992.

154. Ghosh, M., Ghosh, K., and Cohen, J. S. Translation inhibition by phosphorothioate oligodeoxynucleotides, Antisense Res. Dev. 2: 111-118, 1992.

155. Inagaki, M., Togawa, K., Carr, B. I., Ghosh, K., and Cohen, J. S. Physiology of antisense TGF-a oligomers in hepatoma cells., Ann. NY Acad. Sci. 666: 315-317, 1992.

156. Inagaki, M., Togawa, K., Carr, B. I., Ghosh, K., and Cohen, J. S. Antisense oligonucleotides: Inhibition in liver cell proliferation and in vivo disposition., Transplantation Proc. 24: 2971-2972, 1992.

157. Jaroszewski, J. W., Syi, J.-L., Maizel, J., and Cohen, J. S. Towards rational design of antisense DNA: molecular modeling of phosphorothioate DNA analogues, Anticancer Drug Des. 7: 253-262, 1992.

158. Kinchington, D., Galpin, S., Jaroszewski, J. W., Ghosh, K., Subasinghe, C., and Cohen, J. S. A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1, Antivir. Res. 17: 53-62, 1992.

159. Place, D. A., Faustino, P.J., Berghmans, K.K., van Zijl, P.C.M., Chesnick, S.A., Cohen, J.S. MRI contrast-dose relationship of manganese(III)tetra(4-sulfonatophenyl) porphyrin with human xenograft tumors in nude mice at 2.0 Tesla, Magn. Reson. Imaging. 10: 919-928, 1992.

160. Ruiz-Cabello, J., Vuister, G. W., Moonen, C. T. W., van Gelderen, P., Cohen, J. S., and van Zijl, P. C. M. Gradient-enhanced heteronuclear correlation spectroscopy. Theory and experimental aspects, Magn. Reson. Med. 100: 282-302, 1992.

161. Ghosh, M., Ghosh, K., and Cohen, J. S. Oligodeoxynucleotide phosphorothioate- phosphodiester co-polymers: assessment for antisense applications, Anticancer Drug Des. 8: 15-32, 1993.

162. Ghosh, M. K., Ghosh, K., Dahl, O., and Cohen, J. S. Evaluation of properties of a phosphorodithioate oligodeoxynucleotide for antisense application. Nucl. Acids Res. 21: 5761-5766, 1993.

163. Jaroszewski, J., Syi, J.L., Ghosh, M., Ghosh, K., and Cohen, J. S. Targeting of antisense DNA: comparison of activity of anti-rabbit b-globin phosphorothioate oligodeoxynucleotides with computer predictions of mRNA folding. Antisense Res. Devel. 3: 339-348, 1993.

164. Polushin, N. N., Chen, B.-C., Anderson, L. W., and Cohen, J. S. Synthesis and characterization of imidazoyl-linked synthons and 3'-conjugated thymidine derivatives, J. Org. Chem. 58: 4606-4613, 1993.

165. Yaswen, P., Stampfer, M., Ghosh, K., and Cohen, J. S. Effects of sequence of thioated oligonucleotides on cultured epithelial cells, Antisense Res. Devel. 3: 67-77, 1993.

166. Archambault, D., Stein, C. A., and Cohen, J. S. Phosphorothioate oligonucleotides inhibit the replication of lentiviruses and type D retroviruses but not that of type C retroviruses, Arch. Virology. 139: 97-109, 1994.

167. Collier, S. W., Sardon, S., Ruiz-Cabello, J., Johnson, W. A., Cohen, J. S., and Schwartz, S. L. Measurement of pharmacodynamic effects of dexamethasone on epidermis by 31P-NMR spectroscopy in vitro., J. Pharm. Sci. 83: 1339-1344, 1994.

168. Gao, H., Chidambaram, N., Chen, B. C., Pelham, D. E., Patel, R., Yang, M., Zhou, L., Cook, A., and Cohen, J. S. Double stranded cyclic oligonucleotides with non-nucleotide bridges, Bioconjugate Chem. 5: 445-453, 1994.

169. Polushin, N. N., Morocho, M. A., Chen, B.-C., and Cohen, J. S. On the rapid deprotection of synthetic oligonucleotides and analogs, Nucl. Acids Res. 22: 639-645, 1994.

170. Polushin, N., and Cohen, J. S. Antisense pro-drugs: 5'-ester oligodeoxynucleotides, Nucl. Acids Res. 22: 5492-5496, 1994.

171. Ruiz-Cabello, J., Berghmans, K., Kaplan, O., Lippman, M. E., Clarke, R., and Cohen, J. S. Hormone dependence of breast cancer cells and the effects of tamoxifen and estrogen: 31P NMR studies, Breast Cancer Res. & Treat. 33: 209-217, 1994.

172. Ruiz-Cabello, J., Buss, W. C., Collier, S. W., Glazer, R. I., and Cohen, J. S. Changes in ATP after cyclosporin A treatment in a rat renal cell line studies by 31P NMR spectroscopy. Res. Commun. Mol. Path. & Pharm. 86: 3-13, 1994.

173. Zhou, L., Morocho, M., Chen, B. C., and Cohen, J. S. Synthesis of phosphorothioate- methylphosphonate oligonucleotide co-polymers, Nucl. Acids Res. 22: 453-456, 1994.

174. Chidambaram, N., Zhou, L., and Cohen, J. S. Synthesis of steroid-linked and steroid-bridged oligodeoxynucleotides, Drug Delivery. 3: 27-33, 1996.

175. Jaroszewski, J. W., Clausen, V., Cohen, J. S., and Dahl, O. NMR investigations of duplex stability of phosphorothioate and phosphorodithioate DNA analogues modified in both strands. Nucl. Acids Res. 24: 829-834, 1996.

176. Kaplan, O., and Cohen, J. S. In vitro cytotoxicity effects of tumor necrosis factor- in human breast cancer cells may be associated with increased glucose consumption, FEBS Letters. 406: 175-178, 1997.

177. Sardon, S., Lopez-Lacomba, J. L., Collier, S., Sanchez-Alcazar, J. S., Cohen, J. S., and Ruiz-Cabello, J. Effects of percutaneous penetration enhancers on epidermis by in vitro 31P magnetic resonance spectroscopy, J. Mag. Res. Anal.  3: 113-119, 1997.

178. Mardor, Y., Kaplan, O., Sterin, M., Ruiz Cabello, J., Ash, E., Roth, Y., Ringel, I., and Cohen, J. S. Non-invasive real-time monitoring of intracellular cancer cell metabolism and response to lonidamine treatment using diffusion weighted proton MRS, Cancer Res. 60: 5179-5186, 2000.

179. Meidan, V., Cohen, J. S., Amariglio, N., Hirsch-Lerner, D., and Barenholz, Y. Interaction of oligonucleotides with cationic lipids: the relationship between electrostatics, hydration and state of aggregation, Biochim. Biophys. Acta. 1464: 251-261, 2000.

180. Mardor, Y., Roth, Y., Lidar, Z., Jonas, T., Pfeffer, R., Maier, S., Faibel, M., Nass, D., Hadani, M., Orenstein, A., Cohen, J., and Ram, Z. Monitoring Response to Convection-Enhanced Taxol Delivery in Brain Tumor Patients Using Diffusion Weighted MRI, Cancer Res. 61: 4971-4973, 2001.

181. Sterin, M., Cohen, J., Mardor, Y., Berman, E., and Ringel, I. Levels of Phospholipid Metabolites in Breast Cancer Cells Treated with Anti-mitotic Drugs: A 31P Magnetic Resonance Spectroscopy Study, Cancer Res. 61: 7536-7543, 2001.

182. Meidan, V., Glazer, J., Amariglio, N., Cohen, J., and Barenholz, Y. Oligonucleotide lipoplexes: the influence of oligonucleotide composition on complexation, Biochim Biophys Acta. 1568: 177-182, 2001.

183.  Mardor, Y., Pfeffer, R., Spiegelmann, R., Roth, Y., Maier, SE., Nissim O., Berger R., Glicksman A., M., Orenstein, A., Cohen, JS., and Tichler T. Early detection of response to radiation therapy in patients with brain malignancies using standard and high b-value diffusion weighted MRI. J Clin Oncol., 21:1094, 2003.

184. Barbash I., Leor J., Feinberg M., Tessone A., Aboulafia-Etzion S, Orenstein A., Ruiz-Cabello J., Cohen JS, and Mardor Y.  Interventional magnetic resonance imaging for guiding gene and cell transfer in the heart. Heart, 90:87-91, 2004.

185. Roth Y, Tichler, T, Kostenich G, Ruiz-Cabello J, Maier SE, Cohen JS, Orenstein A, and Mardor Y.  High-b Value Diffusion-Weighted MR Imaging for Pretreatment Prediction and Early Monitoring of Tumor Response to Therapy in Mice. Radiology, 232:685-92, 2004.

186. Cohen, J.S., Motiei, M., Carmi, S., Shiperto, D., Yefet, O., and Ringel, I. Determination of intracellular pH using diffusion weighted NMR spectroscopy with pH-sensitive indicators. Magn. Reson. Med., 51: 900-903, 2004.

187. Sterin M, Cohen J, and Ringel, I.  Hormone sensitivity is reflected in the phospholipid profile in breast cancer cells. Breast Cancer Res. & Treat. 87: 1-11, 2004.

188. Meidan, V., Glazer, J., Salomon, S., Sidi, Y., Barenholz, Y., Cohen, J. S., and Lilling, G. Antisense against Bcl-2 in breast cancer cells: A systematic comparison of different lipoplexes, J. Liposome Res. 16: 27-43, 2006.

189. Freikman, I., Amer, J, Cohen, J.S., Ringel, I., and Fibach, E. Oxidative stress causes membrane phospholipid rearrangement and shedding from RBC membranes - an NMR study. Biochem. Biophys. Acta, 1778: 2388-94, 2008.

190. Abramov, Y., Carmi, S., Cohen, J.S., Anteby, S.O., and Ringel, I. 31P Magnetic resonance spectra of ovarian cancer cells exposed to chemotherapy within a three-dimensional Matrigel construct. Oncology Reports, 28: 735-741, 2012.

191. Galindo-Murillo, R., Cohen, J.S., and Akabayov, B. Molecular Dynamics Simulations of Acyclic Analogs of Nucleic Acids for Antisense Inhibition, Molec. Therap. - Nucl. Acids, 23: 527-535, 2020.

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Non-Research Publications:

 

  1. Cohen, J. S. Scientific and Technological Relations, Hearings on Detente before the Sub-Committee on Europe of the House Foreign Affairs Committee. In: Testimony given on behalf of the Committee of Concerned Scientists June, 1974.

  2. Cohen, J. S., and Portugal, F. The Search for the Chemical Structure of DNA, Conn. Med. 38: 551-557, 1974.

  3. Portugal, F., and Cohen, J. S. On the Origins of Molecular Biology, Nature. 250: 791, 1974.

  4. Cohen, J. S., and Portugal, F. A Comment on Historical Analysis in Biochemistry, Perspect. Biol. & Med. 18: 204-207, 1975.

  5. Cohen, J. S. Scientific Societies & Scientists' Rights, Fed. Proc. 37: 1991, 1978.

  6. Cohen, J. S. Limits still tight on Soviet scientists (Book Review of 'Soviet Science' by Zhores Medvedev), Chem. & Eng. News p. 46, 1979.

  7. Cohen, J. S. DNA: Is the Backbone Boring? Trends Biochem. Sci. 5: 58-60, 1980.

  8. Cohen, J. S. NMR and Biochemistry (Book Review), Anal. Biochem. 107: 236, 1980.

  9. Cohen, J. S. Duel in the Laboratory (Book Review of 'The Nobel Duel,' by A. Wade), Chem. & Eng. News p. 48, 1981.

  10. Baltimore, D., et al. Degrees revoked in Soviet Union, Science. 216: 360, 1982.

  11. Cohen, J. S., and Wlodawer, A. Diffraction and NMR Studies of Proteins; an Uneasy Alliance, Trends Biochem. Sci. 7: 389-391, 1982.

  12. Cohen, J. S. Important Compendium on Molecular Biology (Book Review of 'Structural Molecular Biology, Davies, D.B., et al., eds.), Trends Biochem. Sci. 8: 387, 1983.

  13. Cohen, J. S. 2D-NOESY of DNA: As easy as A, B, Z, Trends Biochem. Sci. 12: 133, 1987.

  14. Cohen, J. S. Designing antisense oligonucleotides as pharmaceutical agents, Trends Pharmacol. Sci. 10: 435-437, 1989.

  15. Rothenberg, M., Johnson G., Laughlin, C., Green, L., Cradock, J., Sarver, N., and Cohen, J.S. Oligodeoxynucleotides as antisense inhibitors of gene expression: therapeutic implications, JNCI. 81: 1539, 1989.

  16. Kaplan, O., and Cohen, J. S. Magnetic resonance as a non-invasive tool to study metabolism in pharmacological research, Trends Pharmacol. Sci. 11: 398-400, 1990.

  17. Cohen, J. S. Informational drugs: a new concept in pharmacology, Antisense Res. Dev. 1: 191-193, 1991.

  18. Cohen, J. S. The NIH intramural program, Science. 262: 489-490, 1993.

  19. Cohen, J. S. Genetic Drugs, promise and prospects, Drug News and Perspectives. 7: 340-343, 1994.

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